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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6decreases secretionEXP 6480464CTDNorepinephrine results in decreased secretion of IL6 proteinPMID:16835395
Il6multiple interactionsEXP 6480464CTDANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein]PMID:16835395
Il6increases activityISOIl6 (Rattus norvegicus)6480464CTDNorepinephrine results in increased activity of IL6 proteinPMID:11406463
Il6increases expressionISOIl6 (Rattus norvegicus)6480464CTDNorepinephrine results in increased expression of IL6 mRNA; Norepinephrine results in increased expression of IL6 proteinPMID:10722803 PMID:11406463 PMID:12619890 PMID:14577597 PMID:8392517
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDNorepinephrine results in increased expression of and results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [Norepinephrine results in increased expression of and results in increased secretion of IL6 protein]PMID:18636164
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; ICI 118551 inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]PMID:10722803 PMID:11406463 PMID:12619890 PMID:8392517
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