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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:17941
Term: diisopropyl fluorophosphate
Definition: A dialkyl phosphate that has formula C6H14FO3P.
Chemical ID: MESH:D007531
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionEXP 6480464CTDIsoflurophate results in increased expression of IL6 mRNAPMID:29846716 PMID:30339781
Il6increases secretionEXP 6480464CTDIsoflurophate results in increased secretion of IL6 proteinPMID:30339781
Il6multiple interactionsEXP 6480464CTD[Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; Isoflurophate inhibits the reaction [Corticosterone results in decreased expression of IL6 mRNA]PMID:28500787 PMID:30339781
Il6increases expressionISOIl6 (Rattus norvegicus)6480464CTDIsoflurophate results in increased expression of IL6 mRNA; Isoflurophate results in increased expression of IL6 proteinPMID:28782715 PMID:29272548 PMID:35500718
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTDAEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of IL6 protein]; Corticosterone inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]PMID:28782715 PMID:29272548
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