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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10796
Species: Mus musculus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:53556
Term: toluene 2,4-diisocyanate
Definition: A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID: MESH:D014051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4affects secretionEXP 6480464CTDToluene 2,4-Diisocyanate affects the secretion of IL4 proteinPMID:19150644
Il4increases expressionEXP 6480464CTDToluene 2,4-Diisocyanate results in increased expression of IL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4 proteinPMID:10637130 PMID:11243917 PMID:11467998 PMID:11708898 PMID:12356572 PMID:12789230 PMID:12884401 PMID:12956900 PMID:15590890 PMID:16210060 PMID:16271432 PMID:16940033 PMID:17014439 PMID:17015710 PMID:17257216 PMID:17641053 PMID:17980417 PMID:18652873 PMID:19042193 PMID:19422874 PMID:19428947 PMID:20219652 PMID:22381623 PMID:28826779 PMID:30017638 PMID:30261222
Il4increases secretionEXP 6480464CTDToluene 2,4-Diisocyanate results in increased secretion of IL4 proteinPMID:17693426 PMID:25929181 PMID:28329851 PMID:30517707 PMID:31577921 PMID:33075463 PMID:33711354
Il4multiple interactionsEXP 6480464CTD2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; 4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; [Toluene 2,4-Diisocyanate co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL4 protein; AG 1879 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; AWD 12-281 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; BAY 11-7085 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; bisphenol A promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein]; CD4 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Cilomilast inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; Estradiol promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; FPS-ZM1 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; GSK2193874 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; ICAM1 protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; IL1A protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; IL1B protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Methoxychlor promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; pyrazolanthrone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein]; TNF protein affects the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Toluene 2,4-Diisocyanate results in increased expression of and results in increased secretion of IL4 protein; TSLP protein affects the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]; TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]PMID:12356572 PMID:12789230 PMID:12956900 PMID:15588918 PMID:15590890 PMID:16210060 PMID:17014439 PMID:17015710 PMID:25929181 PMID:28329851 PMID:29846729 PMID:30017638 PMID:30261222 PMID:30517707 PMID:31577921 PMID:33075463 PMID:33711354
Il4increases expressionISOIl4 (Rattus norvegicus)6480464CTDToluene 2,4-Diisocyanate results in increased expression of IL4 mRNA; Toluene 2,4-Diisocyanate results in increased expression of IL4 proteinPMID:11758997 PMID:15950818 PMID:19050374 PMID:19075512 PMID:23333628
Il4increases expressionISOIL4 (Homo sapiens)6480464CTDToluene 2,4-Diisocyanate results in increased expression of IL4 mRNAPMID:20371970
Il4increases secretionISOIL4 (Homo sapiens)6480464CTDToluene 2,4-Diisocyanate results in increased secretion of IL4 proteinPMID:20371970
Il4multiple interactionsISOIl4 (Rattus norvegicus)6480464CTDChlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]; sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]PMID:19050374 PMID:19075512 PMID:23333628
Il4multiple interactionsISOIL4 (Homo sapiens)6480464CTD1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]PMID:20371970
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