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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:5674
Term: herbimycin
Definition: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
Chemical ID: MESH:C020754
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDherbimycin inhibits the reaction [IL1B protein results in decreased expression of VLDLR protein]; herbimycin inhibits the reaction [IL1B protein results in increased activity of TAC1 protein]; herbimycin inhibits the reaction [IL1B protein results in increased expression of TAC1 mRNA]PMID:14622206 PMID:15808840
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