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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bdecreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of IL1B mRNAPMID:37019170
Il1bincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of IL1B mRNA; Chlorpyrifos results in increased expression of IL1B proteinPMID:33839396 PMID:36811218
Il1bmultiple interactionsEXP 6480464CTD[Chlorpyrifos co-treated with Streptozocin] results in increased expression of IL1B mRNA; ginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]PMID:33524429 PMID:36811218
Il1bdecreases expressionISOIl1b (Rattus norvegicus)6480464CTDChlorpyrifos results in decreased expression of IL1B mRNAPMID:33994353
Il1bdecreases expressionISOIL1B (Homo sapiens)6480464CTDChlorpyrifos results in decreased expression of IL1B mRNAPMID:26948828
Il1bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDChlorpyrifos results in increased expression of IL1B mRNA; Chlorpyrifos results in increased expression of IL1B proteinPMID:31823260 PMID:33908150 PMID:35448458
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDChlorpyrifos results in increased expression of IL1B mRNA; Chlorpyrifos results in increased expression of IL1B proteinPMID:30835941 PMID:30978295
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDChlorpyrifos results in increased secretion of IL1B proteinPMID:23994500 PMID:26435000 PMID:35395341
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDHesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Chlorpyrifos results in increased expression of IL1B mRNA]; Plant Extracts inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]PMID:31823260 PMID:33908150 PMID:35448458
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Chlorpyrifos results in increased secretion of IL1B protein]; MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased secretion of IL1B protein]; NFE2L2 protein inhibits the reaction [Chlorpyrifos results in increased expression of IL1B mRNA]; NFE2L2 protein inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]PMID:26435000 PMID:30835941
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