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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTD4,4'-bisphenol F results in increased expression of IL1B mRNA; bisphenol F results in increased expression of IL1B mRNA; bisphenol F results in increased expression of IL1B proteinPMID:31453682 PMID:32044397 PMID:35278557
Il1bincreases secretionEXP 6480464CTDbisphenol F results in increased secretion of IL1B proteinPMID:31453682 PMID:34147605
Il1bmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]; Deoxyglucose inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]; Fulvestrant inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]PMID:34147605
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