GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il1b | increases expression | EXP | | 6480464 | CTD | Bleomycin results in increased expression of IL1B mRNA; Bleomycin results in increased expression of IL1B protein | PMID:16317386 PMID:17118201 PMID:17177178 PMID:19147827 PMID:22687607 PMID:26520185 PMID:26526764 PMID:27704718 PMID:28300665 PMID:28694203 PMID:32032644 PMID:32828905 PMID:36087614 | Il1b | increases secretion | EXP | | 6480464 | CTD | Bleomycin results in increased secretion of IL1B protein | PMID:22687607 PMID:26600069 | Il1b | multiple interactions | EXP | | 6480464 | CTD | 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; [Bleomycin co-treated with Cannabidiol analog] results in decreased expression of IL1B mRNA; [Bleomycin co-treated with Rosiglitazone] results in decreased expression of IL1B mRNA; Calcitriol inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; CEBPB protein affects the reaction [Bleomycin results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Dexamethasone inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; Grape Seed Extract inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; honokiol inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; pirinixic acid inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; PPARA protein affects the reaction [Bleomycin results in increased expression of IL1B protein]; Rosiglitazone inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; SLCO2A1 gene mutant form promotes the reaction [Bleomycin results in increased expression of IL1B mRNA]; TRPM2 gene mutant form inhibits the reaction [Bleomycin results in increased secretion of IL1B protein]; verlukast inhibits the reaction [Bleomycin results in increased expression of IL1B protein]; zileuton inhibits the reaction [Bleomycin results in increased expression of IL1B protein] | PMID:16317386 PMID:17118201 PMID:17177178 PMID:19147827 PMID:26520185 PMID:26526764 PMID:26600069 PMID:27704718 PMID:28300665 PMID:28694203 PMID:30033591 PMID:32032644 PMID:32828905 | Il1b | affects expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Bleomycin affects the expression of IL1B mRNA | PMID:8473757 | Il1b | increases expression | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | Bleomycin results in increased expression of IL1B mRNA; Bleomycin results in increased expression of IL1B protein | PMID:17035056 PMID:26093215 | Il1b | increases expression | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Bleomycin results in increased expression of IL1B mRNA | PMID:35267148 | Il1b | increases secretion | ISO | IL1B (Homo sapiens) | 6480464 | CTD | Bleomycin results in increased secretion of IL1B protein | PMID:37898439 PMID:8473757 | Il1b | multiple interactions | ISO | Il1b (Rattus norvegicus) | 6480464 | CTD | Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; Phytochemicals inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA]; resveratrol inhibits the reaction [Bleomycin results in increased expression of IL1B protein] | PMID:17035056 PMID:26093215 | Il1b | multiple interactions | ISO | IL1B (Homo sapiens) | 6480464 | CTD | IL1B protein promotes the reaction [Bleomycin results in increased expression of CAT protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD1 protein]; IL1B protein promotes the reaction [Bleomycin results in increased expression of SOD2 protein]; yupingfeng inhibits the reaction [Bleomycin results in increased secretion of IL1B protein] | PMID:37898439 PMID:8317554 | | ||||||||||||||||||||||
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