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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10789
Species: Mus musculus
RGD Object: Gene
Symbol: Il1a
Name: interleukin 1 alpha
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1aincreases expressionEXP 6480464CTDbisphenol A results in increased expression of IL1A mRNA; bisphenol A results in increased expression of IL1A proteinPMID:28500084
Il1amultiple interactionsEXP 6480464CTD[Streptozocin co-treated with bisphenol A] results in increased expression of IL1A mRNAPMID:24781736
Il1aaffects expressionISOIl1a (Rattus norvegicus)6480464CTDbisphenol A affects the expression of IL1A mRNAPMID:25181051
Il1aaffects expressionISOIL1A (Homo sapiens)6480464CTDbisphenol A affects the expression of IL1A mRNAPMID:20170705
Il1aincreases methylationISOIl1a (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of IL1A genePMID:28505145
Il1amultiple interactionsISOIL1A (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [IL1A protein promotes the reaction [[RELA protein binds to NFKB1 protein] which binds to CCL2 promoter]]; bisphenol A inhibits the reaction [IL1A protein results in increased expression of CCL2 mRNA]; bisphenol A inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]; fulvestrant inhibits the reaction [bisphenol A inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]]PMID:10614622
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