Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10785
Species: Mus musculus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases expressionEXP 6480464CTDIndomethacin results in decreased expression of IL10 proteinPMID:17329845
Il10increases expressionEXP 6480464CTDIndomethacin results in increased expression of IL10 proteinPMID:10567023
Il10multiple interactionsEXP 6480464CTD(glycyl-glycyl)GLP-2 inhibits the reaction [Indomethacin results in increased expression of IL10 protein]; Indomethacin inhibits the reaction [Zymosan results in increased expression of IL10 protein]; Indomethacin promotes the reaction [Carrageenan results in increased secretion of IL10 protein]; oren gedoku to inhibits the reaction [Indomethacin results in decreased expression of IL10 protein]PMID:10567023 PMID:11301049 PMID:17329845 PMID:29499192
Il10affects expressionISOIl10 (Rattus norvegicus)6480464CTDIndomethacin affects the expression of IL10 proteinPMID:25051504
Il10decreases secretionISOIL10 (Homo sapiens)6480464CTDIndomethacin results in decreased secretion of IL10 proteinPMID:15135802
Il10multiple interactionsISOIl10 (Rattus norvegicus)6480464CTDIndomethacin inhibits the reaction [Carrageenan results in increased expression of IL10 mRNA]PMID:19735303
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTDIndomethacin inhibits the reaction [interferon alfa-n1 results in increased secretion of IL10 protein]PMID:15135802
Go Back to source page   Continue to Ontology report