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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10785
Species: Mus musculus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:31530
Term: edaravone
Definition: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Chemical ID: MESH:C005435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10multiple interactionsISOIl10 (Rattus norvegicus)6480464CTDEdaravone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL10 mRNA]; Edaravone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 mRNA]PMID:12954792 PMID:14567445
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