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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10774
Species: Mus musculus
RGD Object: Gene
Symbol: Igfbp3
Name: insulin-like growth factor binding protein 3
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp3affects expressionISOIgfbp3 (Rattus norvegicus)6480464CTDEthinyl Estradiol affects the expression of IGFBP3 mRNAPMID:20170705 PMID:26865667
Igfbp3affects expressionISOIGFBP3 (Homo sapiens)6480464CTDEthinyl Estradiol affects the expression of IGFBP3 mRNAPMID:20170705 PMID:26865667
Igfbp3decreases expressionISOIgfbp3 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of IGFBP3 mRNAPMID:12655037 PMID:15834898 PMID:16140622 PMID:16174780 PMID:17351261 PMID:17557909
Igfbp3decreases expressionISOIGFBP3 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of IGFBP3 mRNA; Ethinyl Estradiol results in decreased expression of IGFBP3 proteinPMID:10843175 PMID:18936297
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