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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10770
Species: Mus musculus
RGD Object: Gene
Symbol: Igf2
Name: insulin-like growth factor 2
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf2increases acetylationISOIgf2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased acetylation of IGF2 promoterPMID:29094188
Igf2increases expressionISOIgf2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of IGF2 mRNAPMID:29094188
Igf2increases methylationISOIgf2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased methylation of IGF2 promoterPMID:29094188
Igf2multiple interactionsISOIgf2 (Rattus norvegicus)6480464CTDalpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]PMID:29094188
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