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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1raffects methylationISOIgf1r (Rattus norvegicus)6480464CTDMethoxychlor affects the methylation of IGF1R genePMID:35440735
Igf1rdecreases expressionISOIgf1r (Rattus norvegicus)6480464CTDMethoxychlor results in decreased expression of IGF1R mRNAPMID:23303685
Igf1rincreases expressionISOIgf1r (Rattus norvegicus)6480464CTDMethoxychlor results in increased expression of IGF1R mRNA; Methoxychlor results in increased expression of IGF1R proteinPMID:16443925
Igf1rincreases methylationISOIgf1r (Rattus norvegicus)6480464CTDMethoxychlor results in increased methylation of IGF1R genePMID:23303685
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTD[Genistein co-treated with Methoxychlor] results in increased expression of IGF1R mRNA; [Genistein co-treated with Methoxychlor] results in increased expression of IGF1R protein; [Methoxychlor co-treated with Genistein] results in increased expression of IGF1R proteinPMID:11896288 PMID:16443925
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