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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10765
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:3374
Term: capsaicin
Definition: A capsaicinoid that has formula C18H27NO3.
Chemical ID: MESH:D002211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1increases expressionEXP 6480464CTDCapsaicin results in increased expression of IGF1 mRNA; Capsaicin results in increased expression of IGF1 proteinPMID:17307377 PMID:17569567
Igf1multiple interactionsEXP 6480464CTDCALCA protein affects the reaction [Capsaicin results in increased expression of IGF1 mRNA]; CALCA protein affects the reaction [Capsaicin results in increased expression of IGF1 protein]; Isoflavones promotes the reaction [Capsaicin results in increased expression of IGF1 protein]PMID:17569567
Igf1increases expressionISOIgf1 (Rattus norvegicus)6480464CTDCapsaicin results in increased expression of IGF1 proteinPMID:17693108
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDCapsaicin results in increased expression of IGF1 mRNA; Capsaicin results in increased expression of IGF1 proteinPMID:21310942
Igf1multiple interactionsISOIgf1 (Rattus norvegicus)6480464CTDcapsazepine inhibits the reaction [Capsaicin results in increased expression of IGF1 protein]PMID:17693108
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[Capsaicin co-treated with Isoflavones] results in increased expression of IGF1 protein; TRPV1 affects the reaction [Capsaicin results in increased expression of IGF1 mRNA]PMID:19502719 PMID:21310942
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