GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Htr1a | increases expression | EXP | | 6480464 | CTD | Serotonin results in increased expression of HTR1A mRNA | PMID:21083617 | Htr1a | affects binding | ISO | Htr1a (Rattus norvegicus) | 6480464 | CTD | Serotonin binds to HTR1A protein | PMID:21126535 | Htr1a | affects response to substance | ISO | Htr1a (Rattus norvegicus) | 6480464 | CTD | HTR1A protein affects the susceptibility to Serotonin | PMID:16528294 | Htr1a | increases activity | ISO | HTR1A (Homo sapiens) | 6480464 | CTD | Serotonin results in increased activity of HTR1A protein | PMID:31323226 | Htr1a | increases uptake | ISO | Htr1a (Rattus norvegicus) | 6480464 | CTD | HTR1A protein results in increased uptake of Serotonin | PMID:11106871 | Htr1a | multiple interactions | ISO | Htr1a (Rattus norvegicus) | 6480464 | CTD | [1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin; Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]; Guanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]; Guanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Magnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]; Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein] | PMID:11106871 PMID:16528294 PMID:21126535 | Htr1a | multiple interactions | ISO | HTR1A (Homo sapiens) | 6480464 | CTD | Endocannabinoids inhibits the reaction [Serotonin binds to and results in increased activity of HTR1A protein]; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [Serotonin results in increased activity of HTR1A protein]; Serotonin binds to and results in increased activity of HTR1A protein | PMID:30102254 PMID:31323226 | | ||||||||||||||||||||||
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