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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10742
Species: Mus musculus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein 5
Acc ID: CHEBI:7496
Term: nelfinavir
Definition: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.
Chemical ID: MESH:D019888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDNelfinavir results in increased expression of HSPA5; Nelfinavir results in increased expression of HSPA5 proteinPMID:19106637 PMID:20594311 PMID:21355074 PMID:21762082
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDTamoxifen promotes the reaction [Nelfinavir results in increased expression of HSPA5 protein]PMID:20594311
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