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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10742
Species: Mus musculus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein 5
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionISOHspa5 (Rattus norvegicus)6480464CTDnickel sulfate results in increased expression of HSPA5 mRNA; nickel sulfate results in increased expression of HSPA5 proteinPMID:28296042
Hspa5multiple interactionsISOHspa5 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 mRNA]; TEMPO inhibits the reaction [nickel sulfate results in increased expression of HSPA5 protein]PMID:28296042
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