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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10742
Species: Mus musculus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein 5
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]; FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]PMID:18787411
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