GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgb1 | increases secretion | EXP | | 6480464 | CTD | Glucose results in increased secretion of HMGB1 protein | PMID:27783111 | Hmgb1 | multiple interactions | EXP | | 6480464 | CTD | NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein] | PMID:27783111 | Hmgb1 | increases expression | ISO | HMGB1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of HMGB1 mRNA | PMID:19833897 | Hmgb1 | multiple interactions | ISO | HMGB1 (Homo sapiens) | 6480464 | CTD | GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]]; GLO1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]; GLO1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]; Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]; Glucose results in increased expression of and results in increased secretion of HMGB1 protein; JUN promotes the reaction [Glucose results in increased expression of HMGB1 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]; SOD2 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA]; UCP1 inhibits the reaction [Glucose results in increased expression of and results in increased secretion of HMGB1 protein]; UCP1 inhibits the reaction [Glucose results in increased expression of HMGB1 mRNA] | PMID:19833897 | | ||||||||||||||||||||||
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