GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgb1 | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of HMGB1 mRNA | PMID:27601294 | Hmgb1 | multiple interactions | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein; Carbon Tetrachloride results in increased expression of and results in increased secretion of HMGB1 protein; mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA] | PMID:27601294 PMID:30502394 | Hmgb1 | increases expression | ISO | Hmgb1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of HMGB1 mRNA; Carbon Tetrachloride results in increased expression of HMGB1 protein | PMID:22683883 | Hmgb1 | multiple interactions | ISO | Hmgb1 (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein; Curcumin inhibits the reaction [Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein] | PMID:22683883 | | ||||||||||||||||||||||
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