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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10685
Species: Mus musculus
RGD Object: Gene
Symbol: Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin1affects phosphorylationEXP 6480464CTDMorphine affects the phosphorylation of GRIN1 proteinPMID:17996026
Grin1increases phosphorylationEXP 6480464CTDMorphine results in increased phosphorylation of GRIN1 proteinPMID:20519536
Grin1multiple interactionsEXP 6480464CTD[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]PMID:17996026 PMID:20519536
Grin1decreases phosphorylationISOGrin1 (Rattus norvegicus)6480464CTDMorphine results in decreased phosphorylation of GRIN1 proteinPMID:15287884
Grin1increases expressionISOGrin1 (Rattus norvegicus)6480464CTDMorphine results in increased expression of GRIN1 proteinPMID:20950603 PMID:22713680
Grin1multiple interactionsISOGrin1 (Rattus norvegicus)6480464CTDAgmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]PMID:20950603 PMID:22713680
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