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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10675
Species: Mus musculus
RGD Object: Gene
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Got1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of GOT1 mRNAPMID:18343893 PMID:26377647
Got1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of GOT1 mRNAPMID:15328365 PMID:15800033 PMID:16960034 PMID:19770486 PMID:21851831 PMID:21889950 PMID:23864506 PMID:27562557
Got1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of GOT1 mRNAPMID:17942748
Got1multiple interactionsEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of GOT1 mRNA]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOT1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of GOT1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GOT1 promoter]PMID:17942748 PMID:19654925 PMID:21851831 PMID:25975270
Got1decreases expressionISOGOT1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of GOT1 mRNAPMID:20106945 PMID:21632981
Got1increases expressionISOGot1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of GOT1 mRNAPMID:16054898 PMID:16960034 PMID:34747641
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