GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Got1 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of GOT1 mRNA | PMID:18343893 PMID:26377647 | Got1 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of GOT1 mRNA | PMID:15328365 PMID:15800033 PMID:16960034 PMID:19770486 PMID:21851831 PMID:21889950 PMID:23864506 PMID:27562557 | Got1 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of GOT1 mRNA | PMID:17942748 | Got1 | multiple interactions | EXP | | 6480464 | CTD | 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of GOT1 mRNA]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GOT1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of GOT1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GOT1 promoter] | PMID:17942748 PMID:19654925 PMID:21851831 PMID:25975270 | Got1 | decreases expression | ISO | GOT1 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of GOT1 mRNA | PMID:20106945 PMID:21632981 | Got1 | increases expression | ISO | Got1 (Rattus norvegicus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of GOT1 mRNA | PMID:16054898 PMID:16960034 PMID:34747641 | |
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