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GENE - TERM ANNOTATION REPORT

RGD ID: 10669
Species: Mus musculus
RGD Object: Gene
Symbol: Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Acc ID: GO:0005834
Term: heterotrimeric G-protein complex
Definition: Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
Definition Source(s): ISBN:0198547684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 IBAFB:FBgn0001122, FB:FBgn0001123, MGI:MGI:3588268, PANTHER:PTN000026392, PomBase:SPAC23H3.13c, RGD:1304683, RGD:2716, SGD:S000001047, TAIR:locus:2005529, dictyBase:DDB_G02762672290270GO_Central (PMID:21873635)

PMID:21873635
 ISOEMBL:M130062290270MGI (MGI:MGI:56877, PMID:3092218)

MGI:MGI:56877, PMID:3092218
 ISORGD:27162290270RGD GO_REF:0000096, MGI:MGI:4417868
 TAS 2290270MGI (MGI:MGI:58524, PMID:2508088)

MGI:MGI:58524, PMID:2508088
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.