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GENE - TERM ANNOTATION REPORT

RGD ID: 10669
Species: Mus musculus
RGD Object: Gene
Symbol: Gnas
Name: GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
Acc ID: DOID:7004
Term: ACTH-secreting pituitary adenoma
Definition: A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE.
Definition Source(s): MESH:D049913, http://en.wikipedia.org/wiki/Cushing%27s_syndrome
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7369168554872ClinVarClinVar Annotator: match by term: CUSHING DISEASE, PITUITARY

PMID:17493233, PMID:2549426, PMID:7737262
 ISORGD:7369168554872ClinVarClinVar Annotator: match by term: Pituitary adenoma, acth-secreting, somatic

PMID:7737262
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.