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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10669
Species: Mus musculus
RGD Object: Gene
Symbol: Gnas
Name: GNAS complex locus
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gnasdecreases expressionEXP 6480464CTDOzone results in decreased expression of GNAS mRNAPMID:24336422
Gnasmultiple interactionsEXP 6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of GNAS mRNAPMID:27106289
Gnasdecreases expressionISOGnas (Rattus norvegicus)6480464CTDOzone results in decreased expression of GNAS proteinPMID:33146391
Gnasmultiple interactionsISOGnas (Rattus norvegicus)6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of GNAS mRNAPMID:18636392
Gnasmultiple interactionsISOGNAS (Homo sapiens)6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of GNAS mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of GNAS mRNA; [Volatile Organic Compounds co-treated with Ozone] results in decreased expression of GNAS mRNAPMID:32699268
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