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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionEXP 6480464CTDsulforaphane results in increased expression of GCLC mRNA; sulforaphane results in increased expression of GCLC proteinPMID:17942926 PMID:19071154 PMID:19303893 PMID:20932822 PMID:24184564 PMID:27777014
Gclcmultiple interactionsEXP 6480464CTD[sulforaphane co-treated with dibenzoylmethane] results in increased expression of GCLC mRNA; NFE2L2 protein promotes the reaction [sulforaphane results in increased expression of GCLC mRNA]; sulforaphane inhibits the reaction [Acetaminophen results in decreased expression of GCLC mRNA]; sulforaphane inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]PMID:17942926 PMID:20932822 PMID:25818464 PMID:29964319
Gclcdecreases expressionISOGCLC (Homo sapiens)6480464CTDsulforaphane results in decreased expression of GCLC mRNAPMID:35724838
Gclcdecreases methylationISOGCLC (Homo sapiens)6480464CTDsulforaphane results in decreased methylation of GCLC genePMID:31838189
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDsulforaphane results in increased expression of GCLC mRNA; sulforaphane results in increased expression of GCLC proteinPMID:21871945 PMID:22558124
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDsulforaphane results in increased expression of GCLC mRNA; sulforaphane results in increased expression of GCLC proteinPMID:20442190 PMID:21871945 PMID:22558124 PMID:22807314 PMID:28959534 PMID:31518892 PMID:31838189 PMID:34767876
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTDN-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]PMID:21871945
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTDalpha-methylepinine promotes the reaction [sulforaphane results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]; sulforaphane promotes the reaction [alpha-methylepinine results in increased expression of GCLC mRNA]; sulforaphane promotes the reaction [Cisplatin results in increased expression of GCLC mRNA]PMID:21871945 PMID:22807314 PMID:28959534
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