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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of GCLC mRNA; Cadmium Chloride results in increased expression of GCLC proteinPMID:22677785 PMID:29486218
Gclcmultiple interactionsEXP 6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC protein; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GCLC protein]PMID:33398418
Gclcdecreases expressionISOGclc (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of GCLC mRNAPMID:25993096
Gclcdecreases response to substanceISOGCLC (Homo sapiens)6480464CTDGCLC results in decreased susceptibility to Cadmium ChloridePMID:18556457
Gclcdecreases uptakeISOGCLC (Homo sapiens)6480464CTDGCLC results in decreased uptake of Cadmium ChloridePMID:18556457
Gclcincreases expressionISOGclc (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of GCLC mRNAPMID:11254161
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of GCLC mRNA; Cadmium Chloride results in increased expression of GCLC proteinPMID:24291162 PMID:25596134 PMID:26365678 PMID:26525392
Gclcmultiple interactionsISOGclc (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of and results in increased activity of GCLC protein; GCLC affects the reaction [NFE2L2 protein results in decreased susceptibility to Cadmium Chloride]PMID:11254161 PMID:19682480
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of GCLC protein; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]; Cadmium Chloride results in increased expression of and results in increased activity of GCLC protein; Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]PMID:18556457 PMID:25170436 PMID:26365678 PMID:30359721
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