GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclc | increases abundance | EXP | | 6480464 | CTD | GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione | PMID:19914271 PMID:26187465 PMID:7955076 | Gclc | multiple interactions | EXP | | 6480464 | CTD | [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione] | PMID:14978233 PMID:15282320 PMID:15707499 PMID:19914271 PMID:20159942 PMID:22762311 PMID:23628456 PMID:26187465 PMID:7955076 | Gclc | affects chemical synthesis | ISO | GCLC (Homo sapiens) | 6480464 | CTD | GCLC polymorphism affects the chemical synthesis of Glutathione | PMID:16599007 | Gclc | increases abundance | ISO | GCLC (Homo sapiens) | 6480464 | CTD | GCLC results in increased abundance of Glutathione | PMID:18556457 | Gclc | increases expression | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | Glutathione deficiency results in increased expression of GCLC mRNA | PMID:15345336 PMID:20621112 | Gclc | multiple interactions | ISO | Gclc (Rattus norvegicus) | 6480464 | CTD | [HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione | PMID:10544272 | Gclc | multiple interactions | ISO | GCLC (Homo sapiens) | 6480464 | CTD | [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]] | PMID:11673643 PMID:12504668 PMID:17724089 PMID:18556457 PMID:21728338 PMID:21833590 | | ||||||||||||||||||||||
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