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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10652
Species: Mus musculus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:142921
Term: 3-phenylprop-2-enal
Definition: A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name 'cinnamaldehyde' is widely used to refer to the E (trans) isomer.
Chemical ID: MESH:C012843
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDcinnamaldehyde results in increased expression of GCLC mRNA; cinnamaldehyde results in increased expression of GCLC proteinPMID:17178418 PMID:21469739 PMID:30806763
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; [cinnamaldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 mRNA affects the reaction [cinnamaldehyde results in increased expression of GCLC protein]; pyrazolanthrone inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]PMID:20351055 PMID:21469739
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