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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:91091
Term: CHIR 99021
Definition: A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.
Chemical ID: MESH:C473711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionISOGja1 (Rattus norvegicus)6480464CTDChir 99021 results in decreased expression of GJA1 mRNAPMID:34283317
Gja1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene promotes the reaction [Chir 99021 results in decreased expression of GJA1 mRNA]; Chir 99021 inhibits the reaction [FOXA2 protein binds to GJA1 promoter]; Chir 99021 promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA]; Chir 99021 promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 protein]; Chir 99021 promotes the reaction [Benzo(a)pyrene results in decreased expression of GJA1 mRNA]; Chir 99021 promotes the reaction [Benzo(a)pyrene results in decreased expression of GJA1 protein]; Chir 99021 promotes the reaction [CTNNB1 protein binds to GJA1 promoter]; Chir 99021 results in decreased expression of and affects the localization of GJA1 proteinPMID:34283317 PMID:36863560
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