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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of GJA1 protein]; SB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of GJA1 protein]; SB 203580 inhibits the reaction [Resveratrol results in increased expression of GJA1 protein]PMID:23761298 PMID:24449132 PMID:27818224
Gja1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTDSB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]PMID:18445782
Gja1multiple interactionsISOGJA1 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [fulvestrant promotes the reaction [NEDD4 protein binds to and results in increased ubiquitination of GJA1 protein]]; SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 mRNA]; SB 203580 inhibits the reaction [fulvestrant results in decreased expression of GJA1 protein]PMID:29180066
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