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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10621
Species: Mus musculus
RGD Object: Gene
Symbol: Gata1
Name: GATA binding protein 1
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata1affects expressionISOGATA1 (Homo sapiens)6480464CTDHemin affects the expression of GATA1 mRNAPMID:37329354
Gata1decreases expressionISOGATA1 (Homo sapiens)6480464CTDHemin results in decreased expression of GATA1 proteinPMID:37329354
Gata1increases expressionISOGATA1 (Homo sapiens)6480464CTDHemin results in increased expression of GATA1 mRNAPMID:21414390 PMID:23973255 PMID:28552822
Gata1multiple interactionsISOGATA1 (Homo sapiens)6480464CTDcatechol promotes the reaction [Hemin results in increased expression of GATA1 mRNA]; decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; decitabine inhibits the reaction [Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; Hemin promotes the reaction [catechol results in increased expression of GATA1 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]; Phenol inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]PMID:21414390 PMID:23973255 PMID:28552822
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