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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10615
Species: Mus musculus
RGD Object: Gene
Symbol: Gad1
Name: glutamate decarboxylase 1
Acc ID: CHEBI:16643
Term: L-methionine
Definition: The L-enantiomer of methionine.
Chemical ID: MESH:D008715
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gad1decreases expressionEXP 6480464CTDMethionine results in decreased expression of GAD1; Methionine results in decreased expression of GAD1 mRNA; Methionine results in decreased expression of GAD1 proteinPMID:15671176 PMID:16113080 PMID:20442623
Gad1multiple interactionsEXP 6480464CTDMethionine promotes the reaction [MECP2 binds to GAD1 promoter]; Valproic Acid inhibits the reaction [Methionine results in decreased expression of GAD1 protein]PMID:16113080 PMID:20442623
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