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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10600
Species: Mus musculus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbaffects expressionEXP 6480464CTDbisphenol A affects the expression of FSHB mRNAPMID:22875908
Fshbdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of FSHB proteinPMID:32407858 PMID:38021376
Fshbdecreases secretionEXP 6480464CTDbisphenol A results in decreased secretion of FSHB proteinPMID:28393075 PMID:32488702
Fshbincreases expressionEXP 6480464CTDbisphenol A results in increased expression of FSHB mRNAPMID:21182934 PMID:24532816
Fshbmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased expression of FSHB mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate] results in decreased secretion of FSHB protein; Drugs, Chinese Herbal inhibits the reaction [bisphenol A results in decreased secretion of FSHB protein]; KISS1 protein inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]PMID:22828881 PMID:32407858 PMID:32488702
Fshbaffects expressionISOFshb (Rattus norvegicus)6480464CTDbisphenol A affects the expression of FSHB mRNAPMID:25181051
Fshbdecreases expressionISOFshb (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of FSHB mRNA; bisphenol A results in decreased expression of FSHB proteinPMID:19837096 PMID:23554804 PMID:27539358 PMID:31063457 PMID:31424294 PMID:31697385 PMID:35465754
Fshbdecreases secretionISOFshb (Rattus norvegicus)6480464CTDbisphenol A results in decreased secretion of FSHB proteinPMID:25575453 PMID:28959593 PMID:34973380
Fshbincreases expressionISOFshb (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of FSHB mRNA; bisphenol A results in increased expression of FSHB proteinPMID:19782717 PMID:25575453 PMID:27296223 PMID:28641706 PMID:33967032 PMID:34973380
Fshbmultiple interactionsISOFshb (Rattus norvegicus)6480464CTD[4-nonylphenol results in increased susceptibility to bisphenol A] which results in increased secretion of FSHB protein; bisphenol A promotes the reaction [FSHB protein results in increased expression of STAR mRNA]; Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]PMID:28859904 PMID:30228064 PMID:35465754
Fshbmultiple interactionsISOFSHB (Homo sapiens)6480464CTD[FLG gene mutant form affects the susceptibility to bisphenol A] which results in decreased secretion of FSHB protein; bisphenol A inhibits the reaction [FSHB results in increased expression of CYP19A1 mRNA]; bisphenol A inhibits the reaction [FSHB results in increased expression of CYP19A1 protein]; bisphenol A inhibits the reaction [FSHB results in increased expression of IGF1 mRNA]; bisphenol A inhibits the reaction [FSHB results in increased secretion of Estradiol]PMID:20064783 PMID:30245359
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