Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10600
Species: Mus musculus
RGD Object: Gene
Symbol: Fshb
Name: follicle stimulating hormone beta
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fshbmultiple interactionsISOFshb (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [[Estradiol co-treated with FSHB protein] results in increased stability of and results in increased expression of TGFBR3 mRNA]; fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]; fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]; fulvestrant inhibits the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]; fulvestrant inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; fulvestrant inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; fulvestrant inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]PMID:15878966 PMID:18511507 PMID:25549949
Fshbmultiple interactionsISOFSHB (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [CREBBP protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [NCOA1 protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to CYP11A1 gene]]; fulvestrant inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] promotes the reaction [PPARGC1A protein binds to HSD3B gene]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CREBBP protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to CYP11A1 gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to HSD3B gene]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to NCOA1 protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein promotes the reaction [ESR1 protein binds to PPARGC1A protein]]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of CYP11A1 protein]]; fulvestrant inhibits the reaction [TGFB1 protein promotes the reaction [FSHB protein results in increased expression of HSD3B protein]]PMID:18511507
Go Back to source page   Continue to Ontology report