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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10596
Species: Mus musculus
RGD Object: Gene
Symbol: Fos
Name: FBJ osteosarcoma oncogene
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosdecreases expressionEXP 6480464CTDPermethrin results in decreased expression of FOS mRNA; Permethrin results in decreased expression of FOS proteinPMID:11082455 PMID:12111003
Fosmultiple interactionsEXP 6480464CTD[Permethrin co-treated with DDT co-treated with Diethylstilbestrol] inhibits the reaction [Potassium results in increased expression of FOS mRNA]; Permethrin inhibits the reaction [Potassium results in increased expression of FOS mRNA]; Permethrin inhibits the reaction [Veratridine results in increased expression of FOS mRNA]PMID:11082455 PMID:15527870
Fosincreases expressionISOFos (Rattus norvegicus)6480464CTDPermethrin results in increased expression of FOS mRNA; Permethrin results in increased expression of FOS proteinPMID:19017407 PMID:8856738
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