GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fos | decreases activity | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased activity of FOS protein | PMID:29049341 | Fos | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of FOS mRNA | PMID:19410645 PMID:35676786 | Fos | affects expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the expression of FOS mRNA; Arsenic Trioxide affects the expression of FOS protein | PMID:12749819 PMID:19444595 | Fos | decreases expression | ISO | Fos (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of FOS mRNA | PMID:29223816 | Fos | decreases expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of FOS mRNA | PMID:20458559 | Fos | increases expression | ISO | FOS (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of FOS mRNA; Arsenic Trioxide results in increased expression of FOS protein | PMID:11678611 PMID:14682389 PMID:18822310 PMID:23883479 PMID:24956101 PMID:25258189 PMID:25574600 PMID:25791921 PMID:27829220 PMID:29633893 | Fos | multiple interactions | ISO | FOS (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of FOS protein] promotes the reaction [FOS protein binds to CDKN1A promoter]; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of FOS protein] promotes the reaction [FOS protein results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN promoter] which binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN protein] which results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [FOS protein binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [MAPK1 protein promotes the reaction [FOS protein binds to CDKN1A promoter]]; Arsenic Trioxide promotes the reaction [MAPK3 protein promotes the reaction [FOS protein binds to CDKN1A promoter]]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of FOS protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of FOS protein; Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of FOS protein]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [Arsenic Trioxide results in increased expression of FOS protein] | PMID:11678611 PMID:18822310 PMID:23883479 PMID:25791921 | |
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