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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10594
Species: Mus musculus
RGD Object: Gene
Symbol: Fn1
Name: fibronectin 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fn1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of FN1 mRNA; Doxorubicin results in increased expression of FN1 proteinPMID:15033991 PMID:28318631 PMID:29064158
Fn1multiple interactionsEXP 6480464CTD2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]; 2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]PMID:28318631 PMID:29064158
Fn1affects expressionISOFN1 (Homo sapiens)6480464CTDDoxorubicin affects the expression of FN1 mRNA; Doxorubicin affects the expression of FN1 proteinPMID:29385562 PMID:29803840
Fn1affects response to substanceISOFN1 (Homo sapiens)6480464CTDFN1 protein affects the susceptibility to DoxorubicinPMID:16217747
Fn1decreases response to substanceISOFN1 (Homo sapiens)6480464CTDFN1 protein results in decreased susceptibility to DoxorubicinPMID:17703109
Fn1increases expressionISOFn1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of FN1 mRNA; Doxorubicin results in increased expression of FN1 proteinPMID:10430982 PMID:10515446 PMID:30588110 PMID:31307187 PMID:36636964
Fn1increases expressionISOFN1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of FN1 mRNAPMID:37062353
Fn1multiple interactionsISOFn1 (Rattus norvegicus)6480464CTDbenazepril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; celastrol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]; paeonol inhibits the reaction [Doxorubicin results in increased expression of FN1 mRNA]; Ramipril inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]; Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]PMID:10430982 PMID:10515446 PMID:30588110 PMID:31307187 PMID:36636964
Fn1multiple interactionsISOFN1 (Homo sapiens)6480464CTD[Doxorubicin co-treated with ZH-2 compound] results in decreased expression of FN1 protein; [ZH-2 compound results in increased susceptibility to Doxorubicin] which results in decreased expression of FN1 proteinPMID:26701723
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