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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10556
Species: Mus musculus
RGD Object: Gene
Symbol: F2r
Name: coagulation factor II thrombin receptor
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2raffects expressionEXP 6480464CTDProgesterone affects the expression of F2R mRNAPMID:17251523
F2rmultiple interactionsEXP 6480464CTD[N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] which results in increased chemical synthesis of ProgesteronePMID:22207716
F2rincreases expressionISOF2r (Rattus norvegicus)6480464CTDProgesterone results in increased expression of F2R mRNAPMID:11733402 PMID:21770760
F2rmultiple interactionsISOF2R (Homo sapiens)6480464CTD[C186 65 binds to and results in increased activity of F2R protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]; [N3-cyclopropyl-7-((4-(1-methylethyl)phenyl)methyl)-7H-pyrrolo(3, 2-f)quinazoline-1,3-diamine binds to and results in decreased activity of F2R protein] promotes the reaction [CGB3 protein results in increased chemical synthesis of Progesterone]PMID:22207716
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