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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:9635
Term: toremifene
Definition: A tertiary amine that has formula C26H28ClNO.
Chemical ID: MESH:D017312
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases expressionEXP 6480464CTDToremifene results in increased expression of ESR2 mRNAPMID:12079510
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDToremifene binds to and results in decreased activity of ESR2 proteinPMID:25752796
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