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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDRaloxifene Hydrochloride binds to and affects the activity of ESR2 protein alternative form

PMID:15924412
affects expressionISORGD:25826480464CTDRaloxifene Hydrochloride affects the expression of ESR2 mRNA

PMID:19350480
decreases activityISORGD:692136480464CTDRaloxifene Hydrochloride results in decreased activity of ESR2 protein

PMID:17654759
increases activityISORGD:692136480464CTDRaloxifene Hydrochloride results in increased activity of ESR2 protein

PMID:17962382
increases response to substanceISORGD:692136480464CTDESR2 protein results in increased susceptibility to Raloxifene Hydrochloride

PMID:17638070
multiple interactionsISORGD:25826480464CTDESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA], ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]

PMID:24782323
multiple interactionsISORGD:692136480464CTD[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FLNB mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HK1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LBH mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAFF mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAGEA8 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PCTP mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RHOF mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of STK24 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYBU mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ATF3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL8 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DACT1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of EGR1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ENC1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GYG1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of INHBA mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT17 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT34 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NAB1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of OCLN mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PDP1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SOD2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TCIM mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA, [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA, ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EDN3 mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of FLNB mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of IER3 mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of KLRC2 mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MSMB mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA], ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of METTL7A mRNA], ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein], Raloxifene Hydrochloride binds to and results in increased activity of ESR2 protein, Raloxifene Hydrochloride inhibits the reaction [3, 3'-diindolylmethane results in increased expression of ESR2 mRNA], Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter], Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to PTGS2 promoter]

PMID:14699072, PMID:16798746, PMID:17872375, PMID:19059307, PMID:20160136
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.