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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMethoxychlor metabolite results in decreased expression of ESR2 mRNA

PMID:11509743
increases expressionEXP 6480464CTDMethoxychlor metabolite results in increased expression of ESR2 mRNA, Methoxychlor results in increased expression of ESR2 mRNA

PMID:11509743, PMID:21252393
multiple interactionsEXP 6480464CTD[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR2 mRNA, [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of ESR2 mRNA, ESR1 protein inhibits the reaction [Methoxychlor results in increased expression of ESR2 mRNA]

PMID:11509743, PMID:21252393
affects bindingISORGD:692136480464CTDMethoxychlor binds to ESR2 protein

PMID:12224631, PMID:9751507
decreases expressionISORGD:25826480464CTDMethoxychlor results in decreased expression of ESR2 mRNA, Methoxychlor results in decreased expression of ESR2 protein

PMID:18848953, PMID:22285353
increases activityISORGD:692136480464CTDMethoxychlor results in increased activity of ESR2 protein

PMID:26139245
increases methylationISORGD:25826480464CTDMethoxychlor results in increased methylation of ESR2 promoter

PMID:19589859
multiple interactionsISORGD:25826480464CTD[Genistein co-treated with Methoxychlor] results in increased expression of ESR2 mRNA, [o, p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein, Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Methoxychlor inhibits the reaction [FSHB protein results in increased expression of ESR2 mRNA], Methoxychlor inhibits the reaction [FSHB protein results in increased expression of ESR2 protein], Methoxychlor metabolite binds to and results in decreased activity of ESR2 protein

PMID:10579340, PMID:16443925, PMID:25549949, PMID:9492041, PMID:9860891
multiple interactionsISORGD:692136480464CTD[Methoxychlor affects the activity of ESR2 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein], Methoxychlor analog binds to and results in decreased activity of ESR2 protein, Methoxychlor binds to and results in decreased activity of ESR2 protein, Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein], Methoxychlor metabolite binds to and results in decreased activity of ESR2 protein, Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR2 protein]

PMID:10579340, PMID:10999957, PMID:11861976, PMID:14975756, PMID:16626760, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.