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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDDiethylstilbestrol binds to ESR2 protein

PMID:19913605
increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of ESR2 mRNA, Diethylstilbestrol results in increased expression of ESR2 protein, Diethylstilbestrol results in increased expression of ESR2 protein alternative form

PMID:16468032, PMID:22100434, PMID:22710028, PMID:27634370
multiple interactionsEXP 6480464CTD[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with Diethylstilbestrol] results in decreased activity of ESR2 protein, Diethylstilbestrol binds to and results in increased activity of ESR2 protein, ESR2 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 mRNA], ESR2 protein alternative form inhibits the reaction [Diethylstilbestrol results in increased expression of ESR2 protein]

PMID:15465114, PMID:22275727, PMID:26944108, PMID:27634370
affects bindingISORGD:25826480464CTDDiethylstilbestrol binds to ESR2 protein

PMID:19913605
affects bindingISORGD:692136480464CTD[Diethylstilbestrol binds to ESR2 protein] which binds to NCOA2 protein, Diethylstilbestrol binds to ESR2 protein

PMID:10964929, PMID:11518614, PMID:12224631, PMID:15123288, PMID:17287592, PMID:17713618, PMID:19913605, PMID:9751507
increases activityISORGD:692136480464CTDDiethylstilbestrol results in increased activity of ESR2 protein

PMID:19161236
increases expressionISORGD:25826480464CTDDiethylstilbestrol results in increased expression of ESR2 mRNA

PMID:11108262
multiple interactionsISORGD:25826480464CTDDiethylstilbestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein], Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein]

PMID:8650195, PMID:9048584
multiple interactionsISORGD:692136480464CTD[Diethylstilbestrol co-treated with ESR2 protein] results in increased expression of LTF mRNA, Diethylstilbestrol binds to and results in increased activity of ESR2 protein, Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein], Diethylstilbestrol promotes the reaction [ESR2 protein alternative form binds to ESR2 protein alternative form], Diethylstilbestrol promotes the reaction [ESR2 protein binds to EZH2 promoter], Diethylstilbestrol promotes the reaction [ESR2 protein binds to HOTAIR promoter], Diethylstilbestrol promotes the reaction [ESR2 protein binds to HOXA10 promoter], Diethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA1 protein], Diethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA2 protein], ESR2 protein promotes the reaction [Diethylstilbestrol results in increased expression of HOTAIR mRNA]

PMID:10964929, PMID:12765243, PMID:15236964, PMID:16938840, PMID:21783566, PMID:24533973, PMID:25088689, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.