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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:34220
Term: 2,3,4,5-Tetrachloro-4'-biphenylol
Definition: A tetrachlorobenzene that has formula C12H6Cl4O.
Chemical ID: MESH:C427824
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:692136480464CTD2', 3', 4', 5'-tetrachloro-4-biphenylol binds to ESR2 protein

PMID:10964929
multiple interactionsISORGD:692136480464CTD2', 3', 4', 5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR2 protein], 2', 3', 4', 5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA1 protein], 2', 3', 4', 5'-tetrachloro-4-biphenylol promotes the reaction [ESR2 protein binds to NCOA2 protein]

PMID:10964929
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.