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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:17703
Term: 26-hydroxycholesterol
Definition: An oxysterol that is cholesterol substituted at position 26 by a hydroxy group.
Chemical ID: MESH:C076996
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceEXP 6480464CTDESR2 protein affects the susceptibility to 27-hydroxycholesterol

PMID:17873880
multiple interactionsEXP 6480464CTDESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA], ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA]

PMID:17873880
multiple interactionsISORGD:692136480464CTD27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein, 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein, 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

PMID:17872378, PMID:17873880
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.