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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDTestosterone results in decreased expression of ESR2 protein

PMID:15916834
increases expressionEXP 6480464CTDTestosterone results in increased expression of ESR2 mRNA, Testosterone results in increased expression of ESR2 protein

PMID:15916834, PMID:20844152
affects bindingISORGD:692136480464CTDTestosterone binds to ESR2 protein

PMID:19913605
decreases expressionISORGD:25826480464CTDTestosterone results in decreased expression of ESR2 mRNA, Testosterone results in decreased expression of ESR2 protein

PMID:23500659, PMID:26492952, PMID:27866977
increases expressionISORGD:25826480464CTDTestosterone results in increased expression of ESR2 mRNA

PMID:15917159
multiple interactionsISORGD:25826480464CTDMetformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA], Qing Ye Dan inhibits the reaction [Testosterone results in decreased expression of ESR2 protein], Silymarin inhibits the reaction [Testosterone results in decreased expression of ESR2 protein]

PMID:23500659, PMID:26492952, PMID:27866977
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.