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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDEstradiol binds to ESR2 protein

PMID:19913605, PMID:21278053
affects response to substanceEXP 6480464CTDESR2 protein affects the susceptibility to Estradiol

PMID:11145618
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of ESR2 mRNA, Estradiol results in decreased expression of ESR2 protein

PMID:11509743, PMID:17850458, PMID:20574910, PMID:28476547
increases activityEXP 6480464CTDEstradiol results in increased activity of ESR2 protein

PMID:19495926
increases expressionEXP 6480464CTDEstradiol results in increased expression of ESR2 mRNA, Estradiol results in increased expression of ESR2 protein, Estradiol results in increased expression of ESR2 protein alternative form

PMID:14664715, PMID:15916834, PMID:16606610, PMID:17089059, PMID:18281260, PMID:19279558, PMID:22056370, PMID:27634370, PMID:28356238, PMID:30196065
multiple interactionsEXP 6480464CTD4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], [Estradiol co-treated with 2, 2-bis(4-hydroxyphenyl)-1, 1, 1-trichloroethane] results in decreased expression of ESR2 mRNA, [Estradiol co-treated with 2, 2-bis(4-hydroxyphenyl)-1, 1, 1-trichloroethane] results in increased expression of ESR2 mRNA, [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR2 mRNA, [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of ESR2 mRNA, beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], bu-zhong-yi-qi-tang inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Dieldrin inhibits the reaction [Estradiol binds to ESR2 protein], Endosulfan inhibits the reaction [Estradiol binds to ESR2 protein], ESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA], ESR2 affects the reaction [Estradiol results in decreased expression of ESR1 protein], ESR2 affects the reaction [Estradiol results in increased expression of PGR protein], ESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Estradiol], ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein], ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA], Estradiol binds to and affects the activity of ESR2 protein alternative form, Estradiol inhibits the reaction [ESR2 protein alternative form results in increased expression of GNRH1 mRNA], Estradiol inhibits the reaction [Fulvestrant results in decreased expression of ESR2 mRNA alternative form], Fulvestrant inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]], NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form], NCOA1 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein], NCOA2 protein inhibits the reaction [ESR2 protein alternative form inhibits the reaction [Estradiol results in increased expression of ESR2 protein]], NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form], NCOA2 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein], NCOA3 protein promotes the reaction [Estradiol results in increased expression of ESR2 protein alternative form], Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]

PMID:11145618, PMID:11509743, PMID:12834440, PMID:15924412, PMID:16439454, PMID:17089059, PMID:17974624, PMID:20378682, PMID:21278053, PMID:22056370, PMID:27634370, PMID:28356238, PMID:28476547
affects bindingISORGD:25826480464CTDEstradiol binds to ESR2 protein, Estradiol binds to ESR2 protein alternative form

PMID:10619402, PMID:11014220, PMID:15458795, PMID:19913605, PMID:20132880, PMID:9492041
affects bindingISORGD:692136480464CTD[Estradiol binds to ESR2 protein] which binds to NCOA2 protein, ESR2 protein binds to Estradiol, Estradiol analog binds to ESR2 protein, Estradiol binds to ESR2 protein, Estradiol metabolite binds to ESR2 protein

PMID:10964929, PMID:11258963, PMID:11368622, PMID:11507064, PMID:11518614, PMID:12161000, PMID:12224631, PMID:12495555, PMID:12822488, PMID:14723943, PMID:15123288, PMID:15596252, PMID:15946813, PMID:15961563, PMID:16728493, PMID:16839579, PMID:17203231, PMID:19338011, PMID:19913605, PMID:20404318, PMID:20423157, PMID:22989670, PMID:23056236, PMID:25130739, PMID:25786527, PMID:28807876, PMID:29499249, PMID:30742918, PMID:31195007
affects expressionISORGD:25826480464CTDEstradiol affects the expression of ESR2 mRNA, Estradiol affects the expression of ESR2 protein

PMID:22389237, PMID:27463640
affects localizationISORGD:25826480464CTDEstradiol affects the localization of ESR2 protein

PMID:19479021, PMID:22070562
affects response to substanceISORGD:692136480464CTDESR2 protein affects the susceptibility to Estradiol

PMID:17275032
decreases expressionISORGD:25826480464CTDEstradiol results in decreased expression of ESR2 mRNA, Estradiol results in decreased expression of ESR2 protein

PMID:12008023, PMID:12834913, PMID:15458795, PMID:15458797, PMID:15548368, PMID:15979666, PMID:16414171, PMID:16522720, PMID:16614383, PMID:17532555, PMID:19479021, PMID:20381596, PMID:25008887
decreases expressionISORGD:692136480464CTDEstradiol results in decreased expression of ESR2 mRNA, Estradiol results in decreased expression of ESR2 mRNA alternative form, Estradiol results in decreased expression of ESR2 protein

PMID:15118252, PMID:15130599, PMID:16596234, PMID:18700809, PMID:18997820, PMID:29783106
increases activityISORGD:25826480464CTDEstradiol results in increased activity of ESR2 protein

PMID:11583108, PMID:14662790, PMID:15901789, PMID:22166976, PMID:9860891
increases activityISORGD:692136480464CTDEstradiol results in increased activity of ESR2 protein, Estradiol results in increased activity of ESR2 protein alternative form

PMID:11335189, PMID:11875334, PMID:12387416, PMID:12402979, PMID:15064155, PMID:15103026, PMID:15171712, PMID:15319301, PMID:15537743, PMID:16118406, PMID:16756374, PMID:17266178, PMID:17935960, PMID:18486176, PMID:19161236, PMID:19584281, PMID:19654927, PMID:19672399, PMID:20049119, PMID:22613215, PMID:23892311, PMID:26139245, PMID:26778350, PMID:26812056, PMID:27592001, PMID:28248286, PMID:28571686, PMID:28701262, PMID:28717100, PMID:29421333, PMID:29601859, PMID:30017638, PMID:30582956, PMID:30818834, PMID:30951782
increases degradationISORGD:692136480464CTDEstradiol results in increased degradation of ESR2 protein

PMID:14702340
increases expressionISORGD:25826480464CTDEstradiol results in increased expression of ESR2 mRNA, Estradiol results in increased expression of ESR2 protein

PMID:15458797, PMID:16311018, PMID:19094096, PMID:21127968, PMID:22070562
increases expressionISORGD:692136480464CTDEstradiol results in increased expression of ESR2 mRNA, Estradiol results in increased expression of ESR2 mRNA alternative form, Estradiol results in increased expression of ESR2 mRNA mutant form, Estradiol results in increased expression of ESR2 protein

PMID:12377985, PMID:12737316, PMID:14664715, PMID:15207704, PMID:15261991, PMID:16596234, PMID:16739346, PMID:18973785, PMID:20160136, PMID:20836126, PMID:23052036, PMID:23436777, PMID:23982890, PMID:26867312, PMID:28882636, PMID:29063134, PMID:29502166, PMID:29654831, PMID:31278978
increases localizationISORGD:692136480464CTDEstradiol results in increased localization of ESR2 protein

PMID:15171712
increases response to substanceISORGD:692136480464CTDESR2 protein results in increased susceptibility to Estradiol

PMID:21732360
multiple interactionsISORGD:25826480464CTD2, 2', 4, 4', 5-brominated diphenyl ether promotes the reaction [Estradiol results in decreased expression of ESR2 mRNA], 5, 11-diethyl-5, 6, 11, 12-tetrahydrochrysene-2, 8-diol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], [alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of ESR2 mRNA], [Arsenic co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [bisphenol A co-treated with Estradiol co-treated with Triiodothyronine] results in increased expression of ESR2 mRNA, [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [bisphenol A results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in increased expression of ESR2 mRNA, [enzacamene co-treated with Estradiol co-treated with Triiodothyronine] affects the expression of ESR2 mRNA, [Estradiol co-treated with Progesterone] results in decreased expression of ESR2 mRNA, [Estradiol co-treated with Tamoxifen] results in increased expression of ESR2 protein, [Estradiol co-treated with Triiodothyronine] inhibits the reaction [bisphenol A results in decreased expression of ESR2 mRNA], [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA], [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA, afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Androstane-3, 17-diol inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein], ESR1 protein results in decreased susceptibility to [Estradiol co-treated with ESR2 protein], ESR2 protein affects the reaction [Estradiol results in increased expression of SLC6A3 protein], Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR2 mRNA], Estradiol affects the reaction [Oxygen deficiency affects the expression of ESR2 protein], Estradiol binds to and results in increased activity of ESR2 protein, Estradiol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein], Estradiol inhibits the reaction [Estrogens deficiency results in increased expression of ESR2 protein alternative form], Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 mRNA], Estradiol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 protein], Estradiol promotes the reaction [[ESR2 protein binds to FHL1 promoter] which results in decreased expression of FHL1 mRNA], Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR1 protein], Estriol inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Estriol inhibits the reaction [Estradiol binds to ESR2 protein], Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Estrone inhibits the reaction [Estradiol binds to ESR2 protein], Genistein inhibits the reaction [Estradiol affects the expression of ESR2 mRNA], Genistein inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Progesterone inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Tamoxifen inhibits the reaction [Estradiol binds to ESR2 protein alternative form], Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein]

PMID:11014220, PMID:11583108, PMID:16414171, PMID:16451217, PMID:17049845, PMID:19094096, PMID:19460436, PMID:20149813, PMID:21277368, PMID:22166976, PMID:22389237, PMID:24333797, PMID:27338438, PMID:30565903, PMID:8650195, PMID:9048584, PMID:9492041
multiple interactionsISORGD:692136480464CTD1, 1-bis(4-hydroxyphenyl)cyclohexane inhibits the reaction [Estradiol binds to ESR2 protein], 1-hydroxypyrene inhibits the reaction [ESR2 protein binds to Estradiol], 1-naphthol inhibits the reaction [ESR2 protein binds to Estradiol], 2', 3', 4', 5'-tetrachloro-4-biphenylol inhibits the reaction [Estradiol binds to ESR2 protein], 2, 2', 4, 4', 5-brominated diphenyl ether inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 22-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 24-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 25-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 4, 4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol binds to ESR2 protein], 4, 4'-hexafluorisopropylidene diphenol inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 4-methyl-2, 4-bis(4-hydroxyphenyl)pent-1-ene affects the reaction [Estradiol binds to ESR2 protein], 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR2 protein], 5, 11-diethyl-5, 6, 11, 12-tetrahydrochrysene-2, 8-diol inhibits the reaction [[Estradiol co-treated with ESR2] results in increased expression of NOS2 mRNA], 5, 11-diethyl-5, 6, 11, 12-tetrahydrochrysene-2, 8-diol inhibits the reaction [[Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA], 9, 9-bis(4-hydroxyphenyl)fluorene inhibits the reaction [Estradiol results in increased activity of ESR2 protein], 9-phenanthrol inhibits the reaction [ESR2 protein binds to Estradiol], [(all-E) phytoene co-treated with phytofluene] inhibits the reaction [Estradiol results in increased activity of ESR2 protein], [4-(2-phenyl-5, 7-bis(trifluoromethyl)pyrazolo(1, 5-a)pyrimidin-3-yl)phenol results in decreased activity of ESR2 protein] inhibits the reaction [Estradiol results in increased activity of ESR2 protein], [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein, [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein, [ESR2 protein results in increased susceptibility to Estradiol] which results in increased expression of PTEN protein, [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter], [Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to HAVCR2 promoter], [Estradiol binds to ESR2 protein] which affects the folding of ESR2 protein, [Estradiol binds to ESR2 protein] which results in decreased expression of ADM mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of ASAP2 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of BMF mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of CCL3 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of CCL3L3 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of CLCF1 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of CXCL8 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of DMBT1 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of FGF2 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of IGSF9 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of KLF6 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of MYC mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of PKP2 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of PLAU mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of PLEKHF1 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of TGFB2 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of TNFRSF21 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of TRIB1 mRNA, [Estradiol binds to ESR2 protein] which results in decreased expression of ZFP36L1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ABCA3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ACVR1C mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of AFF1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of AGAP4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of AKAP1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ANXA8L1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of APOBEC1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ARHGAP18 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ARHGAP36 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ASB13 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ASCL1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ATP6V1C2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of B3GNT6 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of BCL7A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of BIRC3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of BMP4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of BPIFB1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of BRI3BP mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of C14ORF132 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of C14ORF180 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of C3ORF70 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CABLES2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CACNA2D2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CACNB4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CALCR mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CASP7 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CASQ2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CD22 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CD83 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CDH26 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CGN mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CHPT1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CLASP2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CLCNKA mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CMKLR1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CPN2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CRKL mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CYP1A2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CYP46A1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of CYP4F11 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of DHRS9 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of DNAJA4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of DPEP3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of EGR2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FAM222A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FGD5 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FGF3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FGFBP2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FGFR3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FGR mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FKBP4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FOXK1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of FUT4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GCH1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GCOM1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GHRHR mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GJB3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GPRIN2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GREB1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of GRTP1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of HAR1A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of HDAC4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of HOMER2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of HSD11B2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ID2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of IGSF11 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of IL17RB mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of IL24 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of INPP5A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of KAZN mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of KCNF1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of KCNK6 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of KRT74 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LILRB5 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LOX mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LPAR1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LPL mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LRP5L mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of LRRC74A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MAD1L1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MAG mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MANEAL mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MBOAT1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MCF2L2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MED12L mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of METRNL mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MGAT3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MLPH mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MRAP2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MUC1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYB mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYL10 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYLK3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYOG mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYOT mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of MYT1L mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of NCOA1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of NEFH mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of NPR2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of NRIP1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of NTN4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ONECUT2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of OPRL1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of OSBPL5 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of OTOF mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PAPPA mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PAPSS2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PDE4B mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PDE4C mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PDZK1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PGAP4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PITX1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PKD2L1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PLA2G4D mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PLK2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PLOD2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of POM121L8P mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PTGER3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of PTH1R mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RAB36 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RAET1L mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RCAN1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RGL1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RGS19 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RNF14 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RNF144B mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RPS6KA2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of RUNX3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of S1PR1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of S1PR3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SATB2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SDC4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SH2D3C mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC16A3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC25A19 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC25A42 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC6A3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC9A3R1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLC9A3R2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLCO2A1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SLITRK4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SMTNL2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SNX24 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SOCS1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SOX2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SPIRE2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ST3GAL1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of STAT4 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SYNDIG1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SYNE3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of SYTL5 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TANK mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TAS1R1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TBKBP1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TCF21 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TESK2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TIMP3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TIPARP mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TLN2 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TMEM121B mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TMEM132C mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TP53I3 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TPPP mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3C mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3D mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of TUBA3E mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of UBASH3A mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of UNKL mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of UPF1 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of VPS8 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of VXN mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ZBTB5 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ZNF114 mRNA, [Estradiol binds to ESR2 protein] which results in increased expression of ZSWIM5 mRNA, [Estradiol co-treated with ESR2 protein] results in decreased expression of EGFR mRNA, [Estradiol co-treated with ESR2 protein] results in decreased expression of EGFR protein, [Estradiol co-treated with ESR2 protein] results in increased expression of BGLAP mRNA, [Estradiol co-treated with ESR2 protein] results in increased expression of BSP mRNA, [Estradiol co-treated with ESR2 protein] results in increased expression of LTF mRNA, [Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA, [Estradiol co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA, [Estradiol co-treated with ESR2] results in increased expression of NOS2 mRNA, [Estradiol co-treated with ESR2] results in increased expression of NOS3 mRNA, [Estradiol results in increased activity of ESR2 protein] which results in increased expression of IGFBP4 mRNA, [Estradiol results in increased activity of ESR2 protein] which results in increased expression of MT2A mRNA, Acriflavine inhibits the reaction [Estradiol results in increased activity of ESR2 protein], afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein], afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein], afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]], AHR protein inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Apigenin inhibits the reaction [Estradiol binds to ESR2 protein], benzyl benzoate inhibits the reaction [Estradiol binds to ESR2 protein], benzyl salicylate inhibits the reaction [Estradiol binds to ESR2 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], beta Carotene inhibits the reaction [Estradiol results in increased activity of ESR2 protein], biochanin A inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol A analog inhibits the reaction [Estradiol binds to and results in increased activity of ESR2 protein], bisphenol A analog inhibits the reaction [Estradiol results in increased activity of ESR2 protein], bisphenol A inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol A inhibits the reaction [Estradiol results in increased expression of ESR2 protein], bisphenol B inhibits the reaction [Estradiol binds to ESR2 protein], bisphenol F inhibits the reaction [Estradiol binds to ESR2 protein], Bortezomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR2 protein], butylbenzyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Butyric Acid promotes the reaction [Estradiol results in increased activity of ESR2 protein], carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Chlordecone inhibits the reaction [Estradiol binds to ESR2 protein], citral inhibits the reaction [Estradiol binds to ESR2 protein], Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein], Cycloheximide promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], daidzein inhibits the reaction [Estradiol binds to ESR2 protein], daidzein promotes the reaction [Estradiol results in increased activity of ESR2 protein], di-n-hexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], di-n-octyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], di-n-pentyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Dibutyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Dieldrin promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], Diethylhexyl Phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR2 protein], diisobutyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], diisononyl 1, 2-cyclohexanedicarboxylic acid inhibits the reaction [Estradiol results in increased activity of ESR2 protein], diisononyl 1, 2-cyclohexanedicarboxylic acid metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein], dong quai inhibits the reaction [Estradiol binds to ESR2 protein], Endosulfan promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], ESR2 affects the reaction [Estradiol affects the expression of ESR1 mRNA], ESR2 affects the reaction [Estradiol results in increased expression of KRT19 mRNA], ESR2 protein affects the reaction [Estradiol affects the expression of CCNA2 mRNA], ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA1 protein binds to NKD1 gene]], ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to NKD1 gene]], ESR2 protein affects the reaction [Estradiol promotes the reaction [NCOA2 protein binds to TMEM121B gene]], ESR2 protein affects the reaction [Estradiol results in decreased expression of CDKN1A mRNA], ESR2 protein affects the reaction [Estradiol results in decreased expression of FGFR2 mRNA], ESR2 protein affects the reaction [Estradiol results in decreased expression of PTPRO mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of BCL2 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of CCN5 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of IL24 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of KLK3 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of KRT19 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of MMP12 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of PDCD4 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of RLN2 mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of SMOX mRNA], ESR2 protein affects the reaction [Estradiol results in increased expression of TANK mRNA], ESR2 protein promotes the reaction [Estradiol results in decreased abundance of Reactive Oxygen Species], ESR2 protein promotes the reaction [Estradiol results in decreased expression of ITPR1 mRNA], ESR2 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK1 protein], ESR2 protein promotes the reaction [Estradiol results in increased phosphorylation of MAPK3 protein], Estradiol affects the reaction [daidzein metabolite affects the activity of ESR2 protein], Estradiol affects the reaction [Equol affects the activity of ESR2 protein], Estradiol affects the reaction [kaempferol results in increased activity of ESR2 protein], Estradiol affects the reaction [O-desmethylangolensin affects the activity of ESR2 protein], Estradiol affects the reaction [Quercetin results in increased activity of ESR2 protein], Estradiol affects the reaction [tetrahydrodaidzein affects the activity of ESR2 protein], Estradiol binds to and affects the folding of and results in increased activity of ESR2 protein, Estradiol binds to and results in increased activity of ESR2 protein, Estradiol inhibits the reaction [ESR2 protein affects the expression of CDK5R1 mRNA], Estradiol inhibits the reaction [ESR2 protein affects the expression of TRIM47 mRNA], Estradiol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein], Estradiol inhibits the reaction [royal jelly binds to ESR2 protein], Estradiol promotes the reaction [ESR1 protein binds to ESR2 protein], Estradiol promotes the reaction [ESR2 protein affects the expression of ADAMTSL5 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of ANO1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of ARHGEF39 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of ATP8B3 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CA12 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CACNA1I mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CASP7 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CD34 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CHST8 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CLEC4M mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of COL15A1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of COL18A1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CRISPLD2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CST1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CST5 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of CYP19A1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of ELF3 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of FGD6 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of FIGNL2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of GABBR2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of GALNT12 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of GCOM1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of GREB1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of HAVCR2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of HOXD10 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of HSPB8 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KIF21A mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KRT13 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KRT15 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KRT19 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KRT72 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of KRT86 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of MDFIC mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of METRNL mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of MXD1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of NAV2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of NPR2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of OTOF mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of PADI4 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of PDK4 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of PTGER3 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of RGS10 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SEMA3F mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SH2D3C mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SLC25A42 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SLC45A3 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SLC47A2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SLC6A6 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SPOCD1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of STOX2 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of SYBU mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of TAS1R1 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of TH mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of TNFSF14 mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of TUBA3D mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of VASN mRNA], Estradiol promotes the reaction [ESR2 protein affects the expression of ZFP36 mRNA], Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR2 protein alternative form], Estradiol promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein], Estradiol promotes the reaction [ESR2 protein binds to EZH2 promoter], Estradiol promotes the reaction [ESR2 protein binds to HOXA10 promoter], Estradiol promotes the reaction [ESR2 protein binds to IGF1 promoter], Estradiol promotes the reaction [ESR2 protein binds to KRT19 promoter], Estradiol promotes the reaction [ESR2 protein binds to NCOA1 protein], Estradiol promotes the reaction [ESR2 protein binds to NCOA2 protein], Estradiol promotes the reaction [ESR2 protein binds to NKD1 gene], Estradiol promotes the reaction [ESR2 protein binds to PTGS2 promoter], Estradiol promotes the reaction [ESR2 protein binds to TMEM121B gene], Estradiol promotes the reaction [ESR2 protein results in decreased expression of ADORA2B mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of IL6 mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of INHBE mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of NOG mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of PDE5A mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of SERTAD4 mRNA], Estradiol promotes the reaction [ESR2 protein results in decreased expression of SHOC1 mRNA], Estradiol promotes the reaction [NCOA1 protein binds to ESR2 protein], Estradiol results in increased activity of [ESR1 protein co-treated with ESR2 protein], Estradiol results in increased phosphorylation of and results in increased localization of and results in increased activity of ESR2 protein, Estriol inhibits the reaction [Estradiol binds to ESR2 protein], Eugenol inhibits the reaction [Estradiol binds to ESR2 protein], fenarimol promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], fenpyroximate inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein], fludioxonil inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], fluoxastrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Fulvestrant inhibits the reaction [[Estradiol co-treated with ESR2 protein] results in increased expression of NOS3 mRNA], Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ESR2 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Fulvestrant inhibits the reaction [Estradiol results in increased expression of ESR2 protein], Fulvestrant inhibits the reaction [Estradiol results in increased localization of ESR2 protein], Fulvestrant inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]], Genistein inhibits the reaction [Estradiol binds to ESR2 protein], Genistein promotes the reaction [Estradiol results in increased activity of ESR2 protein], geraniol inhibits the reaction [Estradiol binds to ESR2 protein], hexabrominated diphenyl ether 153 inhibits the reaction [Estradiol results in increased activity of ESR2 protein], kaempferol inhibits the reaction [Estradiol binds to ESR2 protein], kresoxim-methyl inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Lycopene inhibits the reaction [Estradiol results in increased activity of ESR2 protein], methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein], Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein], mono-benzyl phthalate promotes the reaction [Estradiol results in increased activity of ESR2 protein], N-(2, 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], naringenin inhibits the reaction [Estradiol binds to ESR2 protein], pentabrominated diphenyl ether 100 inhibits the reaction [Estradiol results in increased activity of ESR2 protein], perfluorooctane sulfonic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein], perfluorooctanoic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein], Phytoestrogens inhibits the reaction [Estradiol binds to ESR2 protein], picoxystrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Plant Extracts inhibits the reaction [Estradiol binds to ESR2 protein], Polybrominated Biphenyls metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Polychlorinated Biphenyls metabolite inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], prochloraz promotes the reaction [Estradiol results in increased expression of ESR2 mRNA], Propolis inhibits the reaction [Estradiol binds to ESR2 protein], pyridaben inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Quercetin promotes the reaction [Estradiol results in increased activity of ESR2 protein], Resveratrol inhibits the reaction [Estradiol binds to ESR2 protein], Resveratrol promotes the reaction [Estradiol results in increased activity of ESR2 protein], Rotenone inhibits the reaction [Estradiol results in increased activity of ESR2 protein], royal jelly inhibits the reaction [Estradiol binds to ESR2 protein], SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of CASP3 protein], SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein], Sodium Hypochlorite inhibits the reaction [Estradiol binds to ESR2 protein], ST 1481 inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Tamoxifen inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Tamoxifen inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Tetrachlorodibenzodioxin inhibits the reaction [Cycloheximide promotes the reaction [Estradiol results in increased expression of ESR2 mRNA]], Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA mutant form], Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA], Topotecan inhibits the reaction [Estradiol results in increased activity of ESR2 protein], tri-(2-ethylhexyl)trimellitate promotes the reaction [Estradiol results in increased activity of ESR2 protein], trichostatin A promotes the reaction [Estradiol results in increased activity of ESR2 protein], Triclosan inhibits the reaction [Estradiol binds to ESR2 protein], trifloxystrobin inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Trifluridine inhibits the reaction [Estradiol results in increased activity of ESR2 protein], triphenyl phosphate metabolite inhibits the reaction [Estradiol results in increased activity of ESR2 protein], Valproic Acid metabolite promotes the reaction [Estradiol results in increased activity of ESR2 protein], Valproic Acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]

PMID:10964929, PMID:11258963, PMID:11368622, PMID:11507064, PMID:11583108, PMID:12377985, PMID:12399409, PMID:12495555, PMID:12822488, PMID:14699072, PMID:14709801, PMID:14723943, PMID:14742696, PMID:15103026, PMID:15130599, PMID:15171712, PMID:15207704, PMID:15236964, PMID:15261991, PMID:15937998, PMID:15946813, PMID:16079615, PMID:16118406, PMID:16216903, PMID:16566672, PMID:16756374, PMID:16938840, PMID:16965913, PMID:17051425, PMID:17131305, PMID:17135255, PMID:17287592, PMID:17713618, PMID:17872375, PMID:17872378, PMID:17873880, PMID:17935960, PMID:17962382, PMID:17992702, PMID:18486176, PMID:18973785, PMID:19095770, PMID:19264808, PMID:19338011, PMID:19347870, PMID:19426747, PMID:19434490, PMID:19654927, PMID:19672399, PMID:20061804, PMID:20160136, PMID:20332105, PMID:20372779, PMID:20404318, PMID:20427257, PMID:20463317, PMID:20623183, PMID:20836126, PMID:21218783, PMID:21622942, PMID:21732360, PMID:21783566, PMID:22507746, PMID:22613215, PMID:22989670, PMID:23056236, PMID:23436777, PMID:23567241, PMID:23857583, PMID:23892311, PMID:25088689, PMID:25752796, PMID:25786527, PMID:26778350, PMID:26867312, PMID:28248286, PMID:28571686, PMID:28717100, PMID:28807876, PMID:28882636, PMID:29421333, PMID:29601859, PMID:29654831, PMID:30582956, PMID:30818834, PMID:31195007, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.