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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:10106
Term: zearalenone
Definition: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
Chemical ID: MESH:D015025
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDZearalenone binds to ESR2 protein

PMID:19913605
increases expressionEXP 6480464CTDZearalenone results in increased expression of ESR2 mRNA

PMID:30270565
multiple interactionsEXP 6480464CTDDextran Sulfate promotes the reaction [Zearalenone results in increased expression of ESR2 mRNA]

PMID:30270565
affects bindingISORGD:25826480464CTDZearalenone binds to ESR2 protein

PMID:19913605
affects bindingISORGD:692136480464CTDZearalenone analog binds to ESR2 protein, Zearalenone binds to ESR2 protein

PMID:15169976, PMID:19913605, PMID:28807876
decreases expressionISORGD:25826480464CTDZearalenone results in decreased expression of ESR2 mRNA

PMID:27338438
multiple interactionsISORGD:25826480464CTD[bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [bisphenol A co-treated with Zearalenone co-treated with Arsenic co-treated with enzacamene] results in increased expression of ESR2 mRNA, [Estradiol co-treated with Triiodothyronine] promotes the reaction [Zearalenone results in decreased expression of ESR2 mRNA], [Zearalenone co-treated with Estradiol co-treated with Triiodothyronine] results in decreased expression of ESR2 mRNA, [Zearalenone results in increased susceptibility to [Estradiol co-treated with Triiodothyronine]] which results in decreased expression of ESR2 mRNA

PMID:27338438
multiple interactionsISORGD:692136480464CTDZearalenone analog promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein], Zearalenone binds to and results in decreased activity of ESR2 protein, Zearalenone binds to and results in increased activity of ESR2 protein, Zearalenone promotes the reaction [ESR2 protein binds to and results in increased activity of NCOA2 protein]

PMID:15084758, PMID:28807876, PMID:9751507
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.