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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of ESR1 mRNAPMID:24781736
Esr1multiple interactionsEXP 6480464CTDbisphenol A inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]; octylphenol inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]PMID:24781736
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of ESR1PMID:32469605
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[Streptozocin co-treated with Tobacco Smoke Pollution] results in increased expression of ESR1 proteinPMID:30421503
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