GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein | PMID:10620335 | Esr1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | [alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA] | PMID:22975028 PMID:29094188 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of ESR1 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]] | PMID:15253042 PMID:35181438 | | ||||||||||||||||||||||
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